- Title
- Purinergic modulation of glutamate transmission: an expanding role in stress-linked neuropathology
- Creator
- Mayhew, J.; Graham, B. A.; Biber, K.; Nilsson, M.; Walker, F. R.
- Relation
- Neuroscience & Biobehavioral Reviews Vol. 93, Issue October 2018, p. 26-37
- Publisher Link
- http://dx.doi.org/10.1016/j.neubiorev.2018.06.023
- Publisher
- Pergamon Press
- Resource Type
- journal article
- Date
- 2018
- Description
- Chronic stress has been extensively linked to disturbances in glutamatergic signalling. Emerging from this field of research is a considerable number of studies identifying the ability of purines at the pre-, post-, and peri-synaptic levels to tune glutamatergic neurotransmission. While the evidence describing purinergic control of glutamate has continued to grow, there has been relatively little attention given to how chronic stress modulates purinergic functions. The available research on this topic has demonstrated that chronic stress can not only disturb purinergic receptors involved in the regulation of glutamate neurotransmission, but also perturb glial-dependent purinergic signalling. This review will provide a detailed examining of the complex literature relating to glutamatergic-purinergic interactions with a focus on both neuronal and glial contributions. Once these detailed interactions have been described and contextualised, we will integrate recent findings from the field of stress research.
- Subject
- purines; glutamate; neurotransmission; chronic stress
- Identifier
- http://hdl.handle.net/1959.13/1398947
- Identifier
- uon:34503
- Identifier
- ISSN:0149-7634
- Rights
- © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
- Language
- eng
- Full Text
- Reviewed
- Hits: 2868
- Visitors: 3143
- Downloads: 148
Thumbnail | File | Description | Size | Format | |||
---|---|---|---|---|---|---|---|
View Details Download | ATTACHMENT02 | Author final version | 15 MB | Adobe Acrobat PDF | View Details Download |